M.H. Oztop, and K.L. McCarthy
University of California, Davis, CA, USA
In this study, Whey Protein Isolate (WPI) gels of different thickness were soaked in solutions of pH 7.0 and mass uptake was recorded. A finite element model based on diffusion and deformed mesh application modes in COMSOL Multiphysics was developed. Deformed mesh application mode provided the opportunity to incorporate the moving boundaries. The moving boundaries were solved by introducing ...
Modeling Antibiotic Diffusion in a Microfluidic Biofilm Array to Study Bacterial Responses to Antibiotic Concentrations and Combinations
J. Deng, L. Villegas, L. Shor, A. Vázquez, A. Dhummakupt, P. Samson, and J.P. Wikswo
University of Connecticut, Storrs, CT, USA
Instituto Tecnológico y de Estudios Superiores de Monterrey, Monterrey, Mexico
Vanderbilt University, Nashville, TN, USA
Bacteria within a biofilm typically exhibit higher resistance to antibiotic therapy due to mass transport resistance of the biofilm matrix and/or reduced metabolic activity of cells living within the biofilm interior. The objective of this research was to develop a high-throughput experimental and modeling approach to investigate the effects of colony spacing and concentration on the ...
Design of Novel Lithographic Strategies Through Application of Electromagnetic and Multiphysics Simulations
J.P. Singer, J. Lee, S. Ni, M.A. Gibson, S.E. Kooi, and E.L. Thomas
Massachusetts Institute of Technology, Cambridge, MA, USA
Large area patterning techniques such as interference lithography or self-assembly provide 3D nanoscale structures, but lack arbitrary control over what regions are patterned. 3D direct write (DW) lithographic techniques such as multiphoton lithography (MPL) possess the capability to fabricate nearly arbitrary patterns; however, due to the serial nature of DW, fabrication is slow relative to ...
T. Merrill, and A. La Barck
Rowan University, Glassboro, NJ, USA
Reperfusion injury is caused by the rapid restoration of blood flow to oxygen-starved tissue. The model will simulate pulsatile blood flow. A separate 2-dimensional axisymmetric straight tube model will be constructed to simulate the pulsating angioplasty balloon within the flow path. Outlet flow profiles from the straight tube model will then be used as the inlet condition for the ...
T. Ha, and R.A. Canfield
Virginia Polytechnic Institute and State University, Blacksburg, VA, US
Design optimization of slotted waveguide antenna stiffened structures (SWASS) is described. SWASS is a multidisciplinary blending of RF slotted waveguide technology and stiffened composite structures technology. Structural analysis and radio frequency (RF) analysis are integrated. A hat-type stiffened panel is modeled to meet the structure and RF requirements. We are motivated by the potential of ...
University of Washington, Seattle, WA, USA
The standard way of estimating parameters in solving inverse problems is based upon least squares fitting which minimizes the sum of the residuals. Another way of minimizing is based upon the adjoint approach in which the sum of the residuals is augmented by the constraint that the solution satisfies the appropriate algebraic or differential equations. This method involves solving the adjoint ...
K. Song, and H. Knickle
University of Rhode Island, Kingston, RI, USA
As a promising candidate for future electricity providing, solid oxide fuel cell (SOFC) exhibit high efficiency, quiet operation and near zero emissions. In this work, two 2-dimension models of SOFC are constructed in COMSOL. Model 1 includes porous anode and cathode simulations with a thin electrolyte. The fuel cell is operated isothermally under fixed output voltages of 0.4, 0.6 and 0.8. The ...
W.M. Clark, R.C. Shevlin, and T.S. Soffen
Worcester Polytechnic Institute, Worcester, MA, USA
In this poster we present experiments and calculations that investigate these claims and demonstrate how COMSOL Multiphysics can be used in an undergraduate student project to illustrate engineering fundamentals. We measured the temperature of water in glass, aluminum, and plastic bottles as a function of time upon cooling in a refrigerator, cooling in ice water, heating in air, and heating ...
M.E. Karagozler, and S.C. Goldstein
Carnegie Mellon University, Pittsburgh, PA, USA
In this work, we describe the design of a new type of microrobot, the Catom, which is the basic unit of the modular robotic system Claytronics. The Catom is an autonomous, free standing, three dimensional microrobot, which uses electrostatically coupled electrodes to harvest power, actuate, and adhere to other robots. The Catoms are fabricated using lithography based fabrication techniques. The ...
Multiphysics Modeling of Applied Stresses and Strains in an Isolated Biologic Cell During Microfluidic Manipulation
Y. Liang, A. Saha, Z. Shi, R. Marcus, and S.S. Kohles
Central State University, Wilberforce, OH, USA
Portland State University, Portland, OR, USA
In order to test the hypothesis that a controlled external mechanical stimulus may affect cellular regeneration or degeneration, we developed a three-dimensional computational model to explore the applications of a unique micromechanical environment in COMSOL. Recently, experimental stresses have been applied to living cells suspended by an optical trap within microchannel cross-junctional flows. ...